What is augmentin: dosage and side effects

Augmentin (amoxicillin / clavulanate potassium)

What is Augmentin?

Augmentin is a prescription antibiotic. It is used to treat infections caused by bacteria. Augmentin belongs to the penicillin class of antibiotics.

Augmentin contains two drugs: amoxicillin and clavulanic acid. This combination makes Augmentin work against more types of bacteria than antibiotics that contain amoxicillin alone.

Augmentin is effective for treating infections caused by many different types of bacteria. This also includes bacteria that cause:

  • lung infection
  • ear infections
  • Sinus infections
  • skin infections
  • urinary Tract Infections

Augmentin comes in three forms, all of which are taken by mouth:

  • immediately tablet
  • Prolonged-release tablet
  • liquid suspension

Augmentin is available in a generic form. The generic name of Augmentin is amoxicillin / clavulanate potassium.

Generic drugs are often cheaper than the branded version. In some cases, the branded drug and the generic version may be available in different forms and strengths. The generic version of this drug is available in the same forms as Augmentin, as well as in a chewable tablet.

The dose of Augmentin prescribed by your doctor depends on several factors. This includes:

  • the type and severity of the condition you want to treat with Augmentin.
  • your age
  • you take the form of Augmentin
  • other diseases you may have

The following information describes dosages that are commonly used or recommended. However, be sure to take the dose prescribed by your doctor. Your doctor will determine the best dosage for your needs.

Forms and strengths

The three forms of Augmentin come in different strengths:

  • immediate-release tablet: 250 mg / 125 mg, 500 mg / 125 mg, 875 mg / 125 mg
  • Prolonged-release tablet: 1,000 mg / 62.5 mg
  • liquid suspension: 125 mg / 31.25 mg per 5 mL, 250 mg / 62.5 mg per 5 mL

For the above starches, the first number is the amount of amoxicillin and the second number is the amount of clavulanic acid. The ratio of drug to drug is different for each strength, so one strength cannot be replaced by another.

Dosage for urinary tract infections

Immediate release tablets

  • Typical dosage for mild to moderate infections: One 500 mg tablet every 12 hours or one 250 mg tablet every 8 hours.
  • Typical dosage for severe infections: One 875 mg tablet every 12 hours or one 500 mg tablet every 8 hours.
  • Duration of treatment: Usually three to seven days.

Dosage for sinus infection

Immediate release tablets

  • Typical dosage: One 875 mg tablet every 12 hours or one 500 mg tablet every 8 hours.
  • Duration of treatment: Usually five to seven days.

Prolonged-release tablets

  • Typical dosage: Two tablets every 12 hours for 10 days.

Dosage for skin infections such as impetigo

Immediate release tablets

  • Typical dosage: One 500 mg or 875 mg tablet every 12 hours or one 250 mg or 500 mg tablet every 8 hours.
  • Duration of treatment: Usually seven days.

Dosage for ear infections

Immediate release tablets

  • Typical dosage: One 875 mg tablet every 12 hours or one 500 mg tablet every 8 hours.
  • Duration of treatment: Usually 10 days.

Dosage for respiratory infections such as pneumonia

Immediate release tablets

  • Typical dosage: One 875 mg tablet every 12 hours or one 500 mg tablet every 8 hours for 7 to 10 days.

Prolonged-release tablets

  • Typical dosage: Two tablets every 12 hours for 7 to 10 days.

Augmentin suspension for adults

The liquid Augmentin suspension form can be used instead of the tablet for adults who have problems swallowing pills. The suspension is available in different concentrations. Your pharmacist will determine the suspension and amount to be used based on your doctor’s prescription.

Pediatric dosage

The liquid suspension form of Augmentin is typically used for children. The dosage depends on the disease to be treated, its severity and the age or weight of the child.

Your pharmacist will use the doctor’s prescription to determine the concentration of the suspension and the amount your child should take.

For toddlers under 3 months

  • Typical dosage: 30 mg / kg / day (based on the amoxicillin component of Augmentin). This amount is shared and spent every 12 hours.
  • Typical shape used: The 125 mg / 5 mL suspension.

For children from 3 months and older who weigh less than 40 kg.

  • For less severe infections:
  • Typical dosage: 25 mg / kg / day (based on the Amoxicillin component of Augmentin) using the 200 mg / 5 mL or 400 mg / 5 mL suspension. This amount is shared and spent every 12 hours.
  • Alternative dosage: 20 mg / kg / day (based on the amoxicillin component of Augmentin) using the 125 mg / 5 mL or 250 mg / 5 mL suspension. This amount is shared and spent every eight hours.
  • For more severe infections or ear infections, sinus infections or respiratory infections:
    • Typical dosage: 45 mg / kg / day (based on the Amoxicillin component of Augmentin) using the 200 mg / 5 mL or 400 mg / 5 mL suspension. This amount is shared and spent every 12 hours.
    • Alternative dosage: 40 mg / kg / day (based on the amoxicillin component of Augmentin) using the 125 mg / 5 mL or 250 mg / 5 mL suspension. This amount is shared and spent every eight hours.
    • For children over 40 kg (88 lbs)

      • The adult dosage can be used.

      What if I miss a dose??

      If you miss a dose, take it as soon as possible. However, if it is only a few hours until your next dose, skip the missed dose and take the next one on schedule.

      Never try to catch up by taking two doses at the same time. This can lead to dangerous side effects.

      Augmentin side effects

      Augmentin can cause mild or severe side effects. The following list contains some of the main side effects that can occur while taking Augmentin. This list does not include all possible side effects.

      For more information on the possible side effects of Augmentin or for tips on how to deal with a worrying side effect, talk to your doctor or pharmacist.

      More common side effects

      The most common side effects of Augmentin include:

      • diarrhea
      • nausea
      • skin rash
      • Vaginitis (caused by problems like yeast infection)
      • emesis

      These side effects can go away within a few days or weeks. If they are heavier or do not go away, talk to your doctor or pharmacist.

      Severe side effects

      Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you have a medical emergency.

      Serious side effects and their symptoms can be the following:

      • liver problems. It is not common, but some people who take Augmentin can develop liver damage. This appears to be more common in seniors and those who take Augmentin for a long time. Usually these problems go away when the drug is stopped, but in other cases they can be serious and require treatment. Tell your doctor if you experience symptoms of liver problems while taking Augmentin develop. Your doctor can do blood tests to check for liver damage. Symptoms can include:
      • stomach pain
      • fatigue
      • Yellowing of the skin or eyes
    • An intestinal infection. Some people who take antibiotics, including Augmentin, may have an intestinal infection called Clostridium difficile develop. Tell your doctor if you develop symptoms of this infection. Symptoms can include:
      • severe diarrhea that does not go away
      • Stomach pain or cramps
      • nausea
      • Blood in the stool
      • Allergic reaction. Severe allergic reactions can occur in some people taking Augmentin. This is more likely to happen in people with a penicillin allergy. You may not be able to take this medicine again if you have had a serious allergic reaction to it at all. Taking it again could be fatal. If you have had a reaction to this medication in the past, talk to your doctor before taking it again. Symptoms of an allergic reaction can include:
        • severe rash
        • hives
        • Swelling of the lips, tongue and throat
        • difficulty breathing
        • rash

          Many medications, including Augmentin, can cause a rash in some people. This is a common side effect of Augmentin, a penicillin-type antibiotic. This class of antibiotics causes rash more often than most other antibiotics.

          Rash occurs in about 3 percent of people who take Augmentin.

          Elevated, itchy, white or red bumps that appear after the first doses of Augmentin may indicate an allergy to the drug. If so, contact your doctor. If you have an allergic reaction, you may need to be treated with another antibiotic.

          Rashes that develop several days after taking the drug and appear as flat, red spots often indicate another type of rash that is not caused by an allergic reaction. These usually go away on their own after a few days.

          fatigue

          Fatigue is not a common side effect of Augmentin. However, it is common for people fighting infections to feel tired, tired, or weak. If you get tired after starting Augmentin or your symptoms don’t improve, talk to your doctor.

          Yeast Infection

          Vaginal yeast infections can sometimes occur after treatment with antibiotics, including Augmentin. If you have never had a yeast infection and think you may have one, see your doctor for diagnosis and treatment.

          Side effects in children

          Children who take Augmentin can experience the same side effects as adults.

          In addition to these side effects, tooth discoloration may occur in children. Augmentin use can cause a brown, gray, or yellow color in children’s teeth. In most cases, discoloration can be reduced or eliminated by brushing or tooth cleaning.

          Augmentin is widely used in adults and children to treat urinary tract, respiratory, ear, sinus and skin infections. Some of these applications are approved by the Food and Drug Administration (FDA), others are off-label.

          The following information describes some of the most common uses of Augmentin and Augmentin XR.

          Augmentin for urinary tract infections (UTI)

          Augmentin is approved by the FDA for the treatment of UTI. According to the Infectious Diseases Society of America, Augmentin is not an antibiotic of choice for UTI. It should be used when other drugs, such as trimethoprim sulfamethoxazole, cannot be used.

          Augmentin for sinus infection / sinusitis

          Augmentin and Augmentin XR are FDA approved for the treatment of sinus infections in adults and children. Augmentin is considered a drug of choice for this condition.

          Augmentin for streptococci

          Augmentin is not FDA approved for the treatment of Streptococcus pharyngitis. In addition, the Infectious Diseases Society of America does not recommend Augmentin for the treatment of most streptococcal cases.

          Augmentin for pneumonia

          Augmentin and Augmentin XR are approved by the FDA for the treatment of pneumonia. They are usually not the first choice antibiotics for pneumonia. However, they are often used in people with pneumonia who also have other diseases such as diabetes, liver or kidney disease, or heart disease.

          Augmentin and Augmentin XR are typically used in combination with other antibiotics to treat pneumonia.

          Augmentin for ear infections

          Augmentin is FDA approved for the treatment of ear infections, also known as otitis media, in children and adults.

          However, according to the American Academy of Pediatrics, Augmentin is usually not the first choice antibiotic for treating ear infections in children.

          Augmentin is often reserved for children who have recently been treated with another antibiotic, such as amoxicillin. It may also be reserved for those who have had previous ear infections that were not effectively treated with amoxicillin.

          Augmentin for cellulite

          Cellulitis is a type of skin infection. Augmentin is FDA approved to treat some types of skin infections, including cellulite caused by certain bacteria. However, Augmentin is usually not the first choice antibiotic for treating cellulite.

          Augmentin for bronchitis

          Augmentin is approved for the treatment of certain types of respiratory infections. In some cases, this can also be bronchitis.

          Bronchitis is often caused by a virus, so antibiotics are usually not effective in the treatment. But if you have a cough that doesn’t go away and your doctor suspects it’s caused by a bacterial infection, he may consider treating you with antibiotics like Augmentin.

          Augmentin for acne

          Antibiotics are sometimes used to treat certain types of acne. Although it can be used off-label for the treatment of acne, Augmentin is not usually a first choice for this purpose.

          Augmentin for diverticulitis

          Augmentin is not FDA approved for the treatment of diverticulitis. However, it is used off-label to treat it. Augmentin XR is usually considered the second choice antibiotic for diverticulitis.

          Augmentin and alcohol

          Drinking alcohol while taking Augmentin may increase your risk of certain side effects or make your side effects worse.

          Examples of side effects that occur more frequently with alcohol consumption or can worsen include

          • emesis
          • dizziness
          • indigestion
          • liver problems

          Augmentin can interact with various other medications. It can also interact with certain foods.

          Augmentin and other drugs

          Below is a list of medications that can interact with Augmentin. This list does not include all drugs that can interact with Augmentin.

          Different drug interactions can have different effects. For example, some can affect the effects of a medication, others can cause increased side effects.

          Before taking Augmentin, tell your doctor and pharmacist about all prescription, over-the-counter, and other medicines you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid possible interactions.

          If you have any questions about interactions that may affect you, ask your doctor or pharmacist.

          Anticoagulant drugs

          Taking Augmentin with oral anticoagulants such as warfarin (Coumadin, Jantoven) can increase the effectiveness of the anticoagulants. This can lead to increased bleeding.

          If you are taking an anticoagulant drug with Augmentin, your doctor may need to monitor your bleeding risk more often.

          Allopurinol

          Taking Augmentin with allopurinol (Zyloprim, Aloprim) may increase the risk of a rash.

          Oral contraceptives

          Some antibiotics, including Augmentin, may reduce the effectiveness of oral contraceptives (such as birth control pills). Research into this interaction is contradictory and controversial.

          Until more is known about this potential interaction, consider using a backup method of contraception while taking Augmentin.

          Augmentin and Tylenol

          There is no known interaction between Augmentin and Tylenol (acetaminophen).

          Augmentin and milk products

          Milk and other dairy products can interact with some antibiotics. However, they do not interact with Augmentin.

          How to take augmentin

          Take Augmentin exactly as your doctor has told you. You may feel better before you finish all of your treatment. But even if you feel better, don’t stop taking Augmentin. In many cases, it is important to complete the entire treatment so that the infection does not recur.

          If you feel better and want to stop Augmentin early, ask your doctor if it is safe to do so.

          timekeeping

          Augmentin is taken two to three times a day. If you take it twice a day, distribute the doses so that they are about 12 hours apart. If you take it three times a day, distribute the cans so that they are about eight hours apart.

          Augmentin XR is taken twice a day. Spread the cans so that they are about 12 hours apart.

          Augmentin with food

          You can take Augmentin on an empty stomach or with a meal. Eating with a meal can reduce stomach upset and help your body absorb the drug better.

          You should take Augmentin XR at the beginning of a meal. This increases the amount of medication your body absorbs and helps reduce stomach upset.

          Can be crushed Augmentin?

          Augmentin can be crushed. However, Augmentin XR should not be crushed. If one of the two types of tablets is scored (with an indented line), it can be split in half.

          If you have trouble swallowing pills, ask your doctor or pharmacist about taking Augmentin liquid suspension.

          How works Augmentin?

          Augmentin is an antibiotic of the penicillin type. It contains two components: amoxicillin and clavulanic acid. The clavulanic acid ingredient makes Augmentin effective against bacteria that amoxicillin or other penicillin drugs may not work against if taken by themselves.

          Augmentin kills bacteria by attaching to proteins within the bacterial cell. This prevents the bacteria from building up a cell wall, which leads to the death of the bacteria.

          Augmentin is considered a broad-spectrum antibiotic. This means that it works against many different types of bacteria.

          How long does it take for it to work?

          Augmentin begins to work against bacterial infections within hours of taking it. However, you may not notice any improvement in your symptoms for a few days.

          Augmentin and pregnancy

          Augmentin has not been adequately studied in pregnant women to know for sure what effects it could have. Animal studies have found no harm to the fetus when administered to pregnant mothers. However, animal experiments do not always predict how humans would react.

          Augmentin should only be used during pregnancy if there is a clear need.

          Augmentin and breastfeeding

          Augmentin is excreted in breast milk in small amounts. Although it is often considered safe to use while breastfeeding, it can cause side effects in a breastfed baby.

          If you are breast-feeding your child, talk to your doctor before taking Augmentin.

          Augmentin vs. amoxicillin

          Augmentin and amoxicillin can easily be confused with each other, but they are not the same drug.

          Augmentin is amoxicillin?

          No, these are other drugs. Augmentin is a combination drug that contains amoxicillin in addition to another drug.

          The other ingredient, called clavulanic acid, helps amoxicillin in Augmentin against bacteria that are normally resistant to amoxicillin when used alone. (Resistant bacteria do not respond to treatment with a particular antibiotic.)

          Augmentin and amoxicillin are often used to treat similar infections. If your doctor suspects that your infection is resistant to amoxicillin alone, he may recommend Augmentin instead.

          Amoxicillin or Augmentin is stronger?

          Because it contains both amoxicillin and clavulanic acid, Augmentin works against more types of bacteria than amoxicillin alone. In this regard, it could be considered stronger than amoxicillin.

          Augmentin for dogs

          Veterinarians sometimes prescribe Augmentin to treat infections in dogs and cats. The form approved for animals is called Clavamox. It is widely used for skin infections and gum disease in animals, but can also be used for other types of infections.

          If you think your dog or cat has an infection, contact your veterinarian for an assessment and treatment. Different doses of this medication are used for animals as for humans, so don’t try to treat your pet with a human Augmentin recipe.

          If your dog or cat eats your Augmentin prescription, call your veterinarian immediately.

          General questions about Augmentin

          Here you will find answers to some frequently asked questions about Augmentin.

          Augmentin is a type of penicillin?

          Yes, Augmentin is an antibiotic in the penicillin class. It’s called broadband penicillin. This is because it works against many different types of bacteria, including some that are usually resistant to penicillin drugs.

          How long does it take for Augmentin to work?

          Augmentin begins to work within a few hours of taking it. However, your symptoms cannot begin to improve for a few days after.

          Augmentin can make you tired?

          Augmentin does not usually make you tired or sleepy. But when your body is fighting an infection, you tend to feel weak or tired.

          If you are concerned about how tired you feel while taking Augmentin, talk to your doctor.

          If I get diarrhea when I take Augmentin, it means I’m allergic?

          Diarrhea and upset stomach are common side effects of Augmentin. If you experience it, it does not mean that you have an allergy to the drug.

          However, if you have severe diarrhea or diarrhea that does not go away, you should speak to your doctor.

          There are other antibiotics that are often used to treat the same conditions as Augmentin. Some may be better for you than others.

          The best choice of antibiotic may depend on your age, the type and severity of your infection, previous treatments you’ve used, and the patterns of bacterial resistance in your area.

          To find out more about other medications that may work for you, talk to your doctor.

          Alternatives for UTI

          Examples of other drugs that can be used to treat urinary tract infections (UTI) include:

          • Nitrofurantoin (macrobid, macrodantine)
          • Trimethoprim sulfamethoxazole (Bactrim, Sulfatrim)
          • Ciprofloxacin (Cipro, others)
          • Levofloxazine (Levaquin)

          Alternatives for sinus infections

          Examples of other medications that can be used to treat sinus infections include:

          • amoxicillin
          • Doxycycline (Acticlat, Doryx, Doryx MPC, Vibramycin)
          • Levofloxazine (Levaquin)
          • Moxifloxacin (Avelox)

          Alternatives for skin infections

          Examples of other drugs that can be used to treat skin infections include:

          • Doxycycline (Acticlat, Doryx, Doryx MPC, Vibramycin)
          • Cephalexin (Keflex)
          • Penicillin V
          • dicloxacillin
          • Clindamycin (Cleocin)

          Alternatives for ear infections

          Examples of other medications that can be used to treat ear infections include:

          • amoxicillin
          • Cefdinir
          • Cefuroxime (ceftin)
          • cefpodoxime
          • ceftriaxone

          Alternatives to pneumonia

          Examples of other drugs that can be used to treat pneumonia include:

          • Azithromycin (Zithromax)
          • Clarithromycin (biaxin)
          • Erythromycin (Ery-Tab)
          • Doxycycline (Acticlat, Doryx, Doryx MPC)
          • Levofloxazine (Levaquin)
          • Moxifloxacin (Avelox)
          • amoxicillin
          • ceftriaxone
          • cefpodoxime
          • Cefuroxime (ceftin)

          Taking too much of this medication can increase your risk of serious side effects.

          Overdose symptoms

          Symptoms of an overdose of Augmentin can include:

          • nausea
          • emesis
          • stomach pain
          • dizziness
          • Kidney damage or failure

          What to do if you overdose?

          If you think you or your child have taken too much of this medication, call your doctor or seek advice from the American Association of Poison Control Centers at 1-800-222-1222 or through their online tool. But if your symptoms are severe, call 911 or go to the nearest emergency room immediately.

          Overdose

          Treating an overdose depends on the symptoms you have. A doctor can do tests to check for problems with your heart, liver, or kidneys, or for difficulty breathing. You can also check your oxygen levels. In some cases, they can administer intravenous (IV) fluids.

          When Augmentin is dispensed from the pharmacy, the pharmacist adds an expiration date to the label on the bottle. This date is usually one year after the drug is given.

          The purpose of such expiration dates is to ensure the effectiveness of the drug during this time.

          The current stance of the Food and Drug Administration (FDA) is to avoid the use of expired drugs. An FDA-study showed, however, that many medications beyond the expiry date stated on the bottle can be good.

          How long a drug stays good can depend on many factors, how and where it is stored.

          Augmentin pills should be stored in a tightly closed and light-resistant container at room temperature. The dry powder for the liquid suspension should also be stored at room temperature. The mixed liquid suspension should be cooled. It is good for 10 days in the fridge.

          If you have unused medication that has passed its expiry date, talk to your pharmacist about whether you can still use it.

          Warnings for Augmentin

          Before taking Augmentin, talk to your doctor about any medical conditions you have. Augmentin may not be a good choice for you if you have certain medical conditions.

          These conditions include:

          • Allergies to antibiotics. If you have had an allergic reaction to penicillin antibiotics or cephalosporin antibiotics, you are more likely to have an allergic reaction to Augmentin. If you have had an allergic reaction to an antibiotic in the past, tell your doctor before taking Augmentin.
          • liver disease. It is not common, but some people who take Augmentin can develop liver damage. This appears to be more common in those who take Augmentin for a long period of time. If you already have liver disease, your doctor may decide that you should not take Augmentin. Or, they can do blood tests to check your liver function while you are taking Augmentin.
          • mononucleosis. Many people with mononucleosis develop a rash after taking Augmentin. If you have mononucleosis, you shouldn’t take Augmentin.
          • kidney disease. If you have severe kidney disease, you should not take Augmentin XR. However, you may be able to take Augmentin, but your doctor may prescribe it in a lower dose.

          Specialist information for Augmentin

          The following information is provided to clinicians and other healthcare professionals.

          mechanism of action

          Augmentin contains amoxicillin and clavulanic acid. Amoxicillin is a beta-lactam antibiotic with bactericidal activity against gram-negative and gram-positive bacteria.

          Bacteria producing beta-lactamase are resistant to amoxicillin. Clavulanic acid is also a beta-lactam that can inactivate some forms of beta-lactamase.

          The combination of amoxicillin and clavulanic acid expands Augmentin’s spectrum against bacteria that are normally only resistant to amoxicillin.

          Pharmacokinetics and metabolism

          The oral bioavailability of the amoxicillin component of Augmentin is approximately 74 to 92 percent. The peak value of amoxicillin and clavulanic acid is between one and two and a half hours after oral administration.

          The half-life of the amoxicillin component is approximately 1 hour and 20 minutes, for clavulanic acid approximately 1 hour.

          Contraindications

          Augmentin and Augmentin XR are contraindicated in people with severe hypersensitivity reactions to amoxicillin, clavulanic acid, penicillin or cephalosporin antibiotics.

          They are also contraindicated in people with a history of cholestatic jaundice or liver dysfunction after treatment with Augmentin.

          In addition, Augmentin XR is contraindicated in people with severe kidney disease with creatinine clearance less than 30 mL / minute.

          storage

          Augmentin tablets or powder and Augmentin XR should be stored in the original package at temperatures of 77 degrees F (25 degrees C) or less. Reconstituted Augmentin suspensions should be stored in the refrigerator and disposed of after 10 days.

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